CDNF Protects the Nigrostriatal Dopamine System and Promotes Recovery after MPTP Treatment in Mice
نویسندگان
چکیده
منابع مشابه
Effects of noradrenergic lesions on MPTP/MPP+ kinetics and MPTP-induced nigrostriatal dopamine depletions.
Norepinephrine (NE) depletion caused by damage to locus ceruleus neurons was shown to worsen experimental Parkinsonism induced by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in monkeys and in rodents. However, it is not clear whether the lesion to the NE system enhances neurotoxicity in the nigrostriatal dopaminergic (DA) pathway and/or impairs the recovery of DA neurons ...
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ژورنال
عنوان ژورنال: Cell Transplantation
سال: 2012
ISSN: 0963-6897,1555-3892
DOI: 10.3727/096368911x600948